MK-677 (Ibutamoren) is a growth hormone secretagogue which enhances the pulsatile release of GH in the anterior pituitary gland.
MK-677 increases growth hormone levels by mimicking the action of the hormone ghrelin.
It binds to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition
This results in the sustained elevation of insulin-like growth factor (IGF-I) levels, up to 70% above basal natural levels.
Insulin-like growth factor (IGF-I) has been shown to be synthesized by androgen-responsive tissues and to stimulate locally regulated growth.
In addition to their growth-promoting actions, both androgens and IGF-I have metabolic actions in gonadal cells. Similarly, they have been shown to interact in controlling testosterone biosynthesis by leydig cells. IGF-I has been shown to stimulate the testosterone production by testicular interstitial cells and to enhance steroidogenesis by leydig cells.
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