Though a natural product, 5a-Hydroxy Laxogenin has an anabolic/androgenic ratio similar to Anavar, but without side effects like liver toxicity or suppression of testosterone production. It is a good entry point compound for natural athletes, women or those wanting results without complications. Strength will increase in 3-5 days, and lean muscle mass increases in 3-4 weeks. It can also be run indefinitely.
Laxogenin (3beta-hydroxy-25D,5alpha-spirostan-6-one) belongs to a class of plant hormones called brassinosteroids, which have a similar structure to animal steroid hormones. In plants, they work to boost growth.
It is a compound found in nature in underground stems of the Asian plant Smilax sieboldii, which contains approximately 0.06% of the raw form of laxogenin. Laxogenin is also extracted from Chinese onion (Allium chinense) bulbs.
5a-hydroxy laxogenin is produced from the more common plant steroid, diosgenin. Interestingly, diosgenin is used as a raw material for over 50% of synthetic steroids including progesterone, cortisone, and testosterone.
Brassinosteroids are plant-derived polyhydroxylated derivatives of 5a-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids. 28-Homobrassinolide (HB), a steroidal lactone with potent plant growth-promoting property, stimulated protein synthesis and inhibited protein degradation in L6 rat skeletal muscle cells (EC50 4 μM) mediated in part by PI3K/Akt signaling pathway.
Oral administration of HB (20 or 60 mg/kg/d for 24 d) to healthy rats fed normal diet (protein content 23.9%) increased food intake, body weight gain, lean body mass, and gastrocnemius muscle mass as compared with vehicle-treated controls. The effect of HB administration increased slightly in animals fed a high-protein diet (protein content 39.4%).
Both oral (up to 60 mg/kg) and subcutaneous (up to 4 mg/kg) administration of HB showed low androgenic activity when tested in the Hershberger assay. Moreover, HB showed no direct binding to the androgen receptor in vitro. HB treatment was also associated with an improved physical fitness of untrained healthy rats, as evident from a 6.7% increase in lower extremity strength, measured by grip test.
In the gastrocnemius muscle of castrated animals, HB treatment significantly increased the number of type IIa and IIb fibers and the cross-sectional area of type I and type IIa fibers. These findings suggest that oral application of HB triggers selective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals.
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